Anthrax Lethal Toxin Disrupts Intestinal Barrier Function and Causes Systemic Infections with Enteric Bacteria

A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs). Using a murine...

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Detalhes bibliográficos
Main Authors: Sun, Chen, Fang, Hui, Xie, Tao, Auth, Roger D., Patel, Nayana, Murray, Patrick R., Snoy, Philip J., Frucht, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306423/
https://ncbi.nlm.nih.gov/pubmed/22438953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033583
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