Anthrax Lethal Toxin Disrupts Intestinal Barrier Function and Causes Systemic Infections with Enteric Bacteria

A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs). Using a murine...

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Библиографические подробности
Главные авторы: Sun, Chen, Fang, Hui, Xie, Tao, Auth, Roger D., Patel, Nayana, Murray, Patrick R., Snoy, Philip J., Frucht, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306423/
https://ncbi.nlm.nih.gov/pubmed/22438953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033583
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