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Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors

Strategies to ameliorate the flaws of current chemotherapeutic agents, while maintaining potent anticancer activity, are of particular interest. Agents which can modulate multiple targets may have superior utility and fewer side effects than current single-target drugs. To explore the prospect in ca...

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Hlavní autoři: Guerrant, William, Patil, Vishal, Canzoneri, Joshua C., Oyelere, Adegboyega K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306125/
https://ncbi.nlm.nih.gov/pubmed/22260166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200799p
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