Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma

BACKGROUND: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. The presence and prognostic significance of inappropriate mTOR activation have been reported for several cancers. Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are...

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Autors principals: Hirashima, K, Baba, Y, Watanabe, M, Karashima, R-I, Sato, N, Imamura, Y, Nagai, Y, Hayashi, N, Iyama, K-I, Baba, H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305959/
https://ncbi.nlm.nih.gov/pubmed/22333597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.36
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