Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma

BACKGROUND: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. The presence and prognostic significance of inappropriate mTOR activation have been reported for several cancers. Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are...

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Bibliografske podrobnosti
Main Authors: Hirashima, K, Baba, Y, Watanabe, M, Karashima, R-I, Sato, N, Imamura, Y, Nagai, Y, Hayashi, N, Iyama, K-I, Baba, H
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305959/
https://ncbi.nlm.nih.gov/pubmed/22333597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.36
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