Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma

BACKGROUND: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. The presence and prognostic significance of inappropriate mTOR activation have been reported for several cancers. Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are...

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Библиографические подробности
Главные авторы: Hirashima, K, Baba, Y, Watanabe, M, Karashima, R-I, Sato, N, Imamura, Y, Nagai, Y, Hayashi, N, Iyama, K-I, Baba, H
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305959/
https://ncbi.nlm.nih.gov/pubmed/22333597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.36
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