Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

BACKGROUND: Tat-mediated activation of the HIV-1 promoter depends upon a proteasome-associated factor, PAAF1, which dissociates 26S proteasome to produce 19S RP that is essential for transcriptional elongation. The effect of PAAF1 on proteasome activity could also potentially shield certain factors...

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Bibliografiske detaljer
Main Authors: Nakamura, Mirai, Basavarajaiah, Poornima, Rousset, Emilie, Beraud, Cyprien, Latreille, Daniel, Henaoui, Imène-Sarah, Lassot, Irina, Mari, Bernard, Kiernan, Rosemary
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305501/
https://ncbi.nlm.nih.gov/pubmed/22316138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-13
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