Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal

Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3) to regulate gene expression during diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here, we show that Polycomb-like 3 (Pcl3) is a component of PRC2 that promote...

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Main Authors: Hunkapiller, Julie, Shen, Yin, Diaz, Aaron, Cagney, Gerard, McCleary, David, Ramalho-Santos, Miguel, Krogan, Nevan, Ren, Bing, Song, Jun S., Reiter, Jeremy F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305387/
https://ncbi.nlm.nih.gov/pubmed/22438827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002576
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