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Transcription of adenovirus and HeLa cell genes in the presence of drugs that inhibit topoisomerase I and II function.

The requirements for topoisomerases in transcription of adenovirus and HeLa cell genes were analyzed using drugs that specifically inhibit either topoisomerases I or II. Cleavage of viral DNA by topoisomerases in the presence of either camptothecin or VM26 was used to determine drug concentrations t...

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Autors principals: Schaak, J, Schedl, P, Shenk, T
Format: Artigo
Idioma:Inglês
Publicat: 1990
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC330517/
https://ncbi.nlm.nih.gov/pubmed/2158079
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