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Computational modeling of the potential interactions of the proteasome β5 subunit and catechol-O-methyltransferase-resistant EGCG analogs

(−)-Epigallocatechin gallate [(−)-EGCG] has been implicated in cancer chemoprevention and has been shown as an inhibitor of tumor proteasomal chymotrypsin-like activity in vitro and in vivo. However, EGCG is subjected to rapid biotransforming modifications such as methylation by catechol-O-methyltra...

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Bibliografiske detaljer
Main Authors: KANWAR, JYOTI, MOHAMMAD, IMTHIYAZ, YANG, HUANJIE, HUO, CONGDE, CHAN, TAK HANG, DOU, Q. PING
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304469/
https://ncbi.nlm.nih.gov/pubmed/20596600
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