The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting

BACKGROUND: Novel treatment strategies are needed to cure disseminated Ewing sarcoma. Primitive neuroectodermal features and a mesenchymal stem cell origin are both compatible with aberrant expression of the ganglioside antigen G(D2) and led us to explore G(D2) immune targeting in this cancer. METHO...

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Bibliographische Detailangaben
Hauptverfasser: Kailayangiri, S, Altvater, B, Meltzer, J, Pscherer, S, Luecke, A, Dierkes, C, Titze, U, Leuchte, K, Landmeier, S, Hotfilder, M, Dirksen, U, Hardes, J, Gosheger, G, Juergens, H, Rossig, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304425/
https://ncbi.nlm.nih.gov/pubmed/22374462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.57
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