2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells

PURPOSE: Novel natural killer (NK) cell-directed strategies in cancer immunotherapy aim at specifically modulating the balance between NK cell receptor signals towards tumor-specific activation. The signaling lymphocyte activation molecule (SLAM)-related receptor 2B4 (CD244) is an important regulato...

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Hauptverfasser: Altvater, Bianca, Landmeier, Silke, Pscherer, Sibylle, Temme, Jaane, Schweer, Katharina, Kailayangiri, Sareetha, Campana, Dario, Juergens, Heribert, Pule, Martin, Rossig, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771629/
https://ncbi.nlm.nih.gov/pubmed/19638467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2810
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