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Cytokine receptor modulation by interleukin-2 broadly regulates T helper cell lineage differentiation
T helper (T(H)) cells control host-defense to pathogens. The receptors for IL-12, IL-4, and IL-6 are required for T(H)1, T(H)2, and T(H)17 differentiation, respectively. IL-2 signaling via the transcription factor STAT5 controls T(H)2 differentiation by regulating the T(H)2 cytokine gene cluster and...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304099/ https://ncbi.nlm.nih.gov/pubmed/21516110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2030 |
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