Priming for T helper type 2 differentiation by interleukin 2-mediated induction of IL-4 receptor α chain expression

T-helper type 2 (T(H)2) cells are essential for humoral immunity and host defense. Interleukin (IL)-4 drives T(H)2 differentiation and IL-2 augments Il4 chromatin accessibility. Here we demonstrated that IL-2, by inducing STAT5 binding to the Il4ra locus, is essential for inducing and maintaining IL...

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Hauptverfasser: Liao, Wei, Schones, Dustin E., Oh, Jangsuk, Cui, Yongzhi, Cui, Kairong, Tae-Young, Roh, Zhao, Keji, Leonard, Warren J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762127/
https://ncbi.nlm.nih.gov/pubmed/18820682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1656
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