Merging Pharmacometabolomics with Pharmacogenomics using “1000 Genomes” SNP Imputation: Selective Serotonin Reuptake Inhibitor Response Pharmacogenomics

OBJECTIVE: We set out to test the hypothesis that pharmacometabolomic data could be efficiently merged with pharmacogenomic data by SNP imputation of metabolomic-derived pathway data on a “scaffolding” of genome-wide association (GWA) SNP data to broaden and accelerate “pharmacometabolomics-informed...

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Main Authors: Abo, Ryan, Hebbring, Scott, Ji, Yuan, Zhu, Hongjie, Zeng, Zhao-Bang, Batzler, Anthony, Jenkins, Gregory D., Biernacka, Joanna, Snyder, Karen, Drews, Maureen, Fiehn, Oliver, Fridley, Brooke, Schaid, Daniel, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki, Mushiroda, Taisei, Kaddurah-Daouk, Rima, Mrazek, David A., Weinshilboum, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303952/
https://ncbi.nlm.nih.gov/pubmed/22322242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835001c9
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