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Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells.

Fostriecin causes a delayed inhibition of replicative DNA synthesis in human cells, consistent with a role for DNA topoisomerase II (its target enzyme) at a late stage in replication. Fostriecin does not inhibit UV-induced excision repair. The less specific inhibitor novobiocin blocks repair in perm...

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Bibliografische gegevens
Hoofdauteurs: Gedik, C M, Collins, A R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1990
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC330357/
https://ncbi.nlm.nih.gov/pubmed/2156221
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