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The structure of a pre-mRNA molecule in solution determined with a site directed cross-linking reagent.

We describe the use of site specific psoralen (SSP) to determine the solution structure of a segment of the human beta globin pre-mRNA. In these experiments, SSP is first delivered as monoadducts to specific nucleotides in the pre-mRNA and subsequently used to form intramolecular RNA-RNA cross-links...

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Bibliografiske detaljer
Main Authors: Teare, J, Wollenzien, P
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC330337/
https://ncbi.nlm.nih.gov/pubmed/2315042
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