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The structure of a pre-mRNA molecule in solution determined with a site directed cross-linking reagent.
We describe the use of site specific psoralen (SSP) to determine the solution structure of a segment of the human beta globin pre-mRNA. In these experiments, SSP is first delivered as monoadducts to specific nucleotides in the pre-mRNA and subsequently used to form intramolecular RNA-RNA cross-links...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1990
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2315042/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.4.855 |
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