α-Mangostin Induces Apoptosis and Suppresses Differentiation of 3T3-L1 Cells via Inhibiting Fatty Acid Synthase

α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50) value of 20 µM was incomplicated in apoptotic...

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Detalhes bibliográficos
Main Authors: Quan, Xiaofang, Wang, Yi, Ma, Xiaofeng, Liang, Yan, Tian, Weixi, Ma, Qingyun, Jiang, Hezhong, Zhao, Youxing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302861/
https://ncbi.nlm.nih.gov/pubmed/22428036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033376
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