Systemic IL-12 Administration Alters Hepatic Dendritic Cell Stimulation Capabilities

The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic IL-12 administration can improve responses to tumors, the effects of IL-12-based treatments on DC, in particular hepatic DC, remain incomple...

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Autori principali: Chan, Tim, Back, Timothy C., Subleski, Jeffrey J., Weiss, Jonathan M., Ortaldo, John R., Wiltrout, Robert H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302816/
https://ncbi.nlm.nih.gov/pubmed/22428016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033303
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