Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gra...

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Main Authors: Sonveaux, Pierre, Copetti, Tamara, De Saedeleer, Christophe J., Végran, Frédérique, Verrax, Julien, Kennedy, Kelly M., Moon, Eui Jung, Dhup, Suveera, Danhier, Pierre, Frérart, Françoise, Gallez, Bernard, Ribeiro, Anthony, Michiels, Carine, Dewhirst, Mark W., Feron, Olivier
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302812/
https://ncbi.nlm.nih.gov/pubmed/22428047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033418
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