HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1) infection through an interaction with capsid (CA), preventing virus nuclear entry and integration. HIV-1 acquires resistance to CPSF6-358 through an N74D mutation of CA that impairs binding of the antiviral factor....

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, KyeongEun, Mulky, Alok, Yuen, Wendy, Martin, Thomas D., Meyerson, Nicholas R., Choi, Laura, Yu, Hyun, Sawyer, Sara L., KewalRamani, Vineet N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302544/
https://ncbi.nlm.nih.gov/pubmed/22301135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06607-11
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