An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses

Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which e...

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Bibliografische gegevens
Hoofdauteurs: Helguera, Gustavo, Jemielity, Stephanie, Abraham, Jonathan, Cordo, Sandra M., Martinez, M. Guadalupe, Rodríguez, José A., Bregni, Carlos, Wang, Jinyize J., Farzan, Michael, Penichet, Manuel L., Candurra, Nélida A., Choe, Hyeryun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
Onderwerpen:
Vaccines and Antiviral Agents
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302512/
https://ncbi.nlm.nih.gov/pubmed/22278244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06397-11
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