An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses

Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which e...

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Detalhes bibliográficos
Main Authors: Helguera, Gustavo, Jemielity, Stephanie, Abraham, Jonathan, Cordo, Sandra M., Martinez, M. Guadalupe, Rodríguez, José A., Bregni, Carlos, Wang, Jinyize J., Farzan, Michael, Penichet, Manuel L., Candurra, Nélida A., Choe, Hyeryun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302512/
https://ncbi.nlm.nih.gov/pubmed/22278244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06397-11
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