A Noncanonical mu-1A-Binding Motif in the N Terminus of HIV-1 Nef Determines Its Ability To Downregulate Major Histocompatibility Complex Class I in T Lymphocytes

Downregulation of major histocompatibility complex class I (MHC-I) by HIV-1 Nef protein is indispensable for evasion of protective immunity by HIV-1. Though it has been suggested that the N-terminal region of Nef contributes to the function by associating with a mu-1A subunit of adaptor protein 1, t...

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Bibliographische Detailangaben
Hauptverfasser: Iijima, Sayuki, Lee, Young-Jung, Ode, Hirotaka, Arold, Stefan T., Kimura, Nobuyuki, Yokoyama, Masaru, Sato, Hironori, Tanaka, Yasuhito, Strebel, Klaus, Akari, Hirofumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302484/
https://ncbi.nlm.nih.gov/pubmed/22301137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06257-11
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