The Identification of a Small Molecule Compound That Reduces HIV-1 Nef-Mediated Viral Infectivity Enhancement

Nef is a multifunctional HIV-1 protein that accelerates progression to AIDS, and enhances the infectivity of progeny viruses through a mechanism that is not yet understood. Here, we show that the small molecule compound 2c reduces Nef-mediated viral infectivity enhancement. When added to viral produ...

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Main Authors: Chutiwitoonchai, Nopporn, Hiyoshi, Masateru, Mwimanzi, Philip, Ueno, Takamasa, Adachi, Akio, Ode, Hirotaka, Sato, Hironori, Fackler, Oliver T., Okada, Seiji, Suzu, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217016/
https://ncbi.nlm.nih.gov/pubmed/22110726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027696
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