Formation of Higher-Order Foot-and-Mouth Disease Virus 3D(pol) Complexes Is Dependent on Elongation Activity

The replication of many viruses involves the formation of higher-order structures or replication “factories.” We show that the key replication enzyme of foot-and-mouth disease virus (FMDV), the RNA-dependent RNA polymerase, forms fibrils in vitro. Although there are similarities with previously char...

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Detalhes bibliográficos
Main Authors: Bentham, Matthew, Holmes, Kris, Forrest, Sophie, Rowlands, David J., Stonehouse, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302376/
https://ncbi.nlm.nih.gov/pubmed/22156531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05696-11
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