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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
Replicative stress (RS) is a type of endogenous DNA damage that cells suffer every time they duplicate their genomes, and which is further boosted by oncogenes. In mammals, the RS response (RSR) is coordinated by ATR and Chk1 kinases. We sought to develop a mammalian organism that is selectively pro...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302228/ https://ncbi.nlm.nih.gov/pubmed/22370720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112147 |
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