Fos-dependent induction of Chk1 protects osteoblasts from replication stress

Stable Fos expression in the osteoblast lineage results in the development of osteosarcomas (OS) in mice, yet the underlying mechanisms are poorly understood. Using a genetic system in which Fos expression can be induced in osteoblasts in a doxycycline-dependent manner and through subsequent RNA seq...

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Main Authors: Schulze, Jochen, Lopez-Contreras, Andres J, Uluçkan, Özge, Graña-Castro, Osvaldo, Fernandez-Capetillo, Oscar, Wagner, Erwin F
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111761/
https://ncbi.nlm.nih.gov/pubmed/24762558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28923
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