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Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6
Hepcidin is the master regulator of iron homeostasis. In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv) whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3302207/ https://ncbi.nlm.nih.gov/pubmed/20940420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-295147 |
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