Antiproliferative Mechanisms of Action of the Flavin Dehydrogenase Inhibitors Diphenylene Iodonium and Di-2-thienyliodonium Based on Molecular Profiling of the NCI-60 Human Tumor Cell Panel

Flavoprotein-dependent reactive oxygen species (ROS) play a critical role in cytokine-mediated signal transduction in normal tissues and tumor cells. The flavoenzyme inhibitors diphenylene iodonium (DPI) and di-2-thienyliodonium (DTI) have been used to inhibit membrane-bound, flavoprotein-containing...

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Autores principales: Doroshow, James H., Juhasz, Agnes, Ge, Yun, Holbeck, Susan, Lu, Jiamo, Antony, Smitha, Wu, Yongzhong, Jiang, Guojian, Roy, Krishnendu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299930/
https://ncbi.nlm.nih.gov/pubmed/22305747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.01.022
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