Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission

Previously, we have shown that the GABA synthesizing enzyme, L-glutamic acid decarboxylase 65 (GAD65) is cleaved to form its truncated form (tGAD65) which is 2–3 times more active than the full length form (fGAD65). The enzyme responsible for cleavage was later identified as calpain. Calpain is know...

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Détails bibliographiques
Auteurs principaux: Buddhala, Chandana, Suarez, Marjorie, Modi, Jigar, Prentice, Howard, Ma, Zhiyuan, Tao, Rui, Wu, Jang Yen
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299728/
https://ncbi.nlm.nih.gov/pubmed/22427928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033002
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