Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis

BACKGROUND: Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. The JAK2 V617F mutation and PRV1 gene overexpression may contribute to MPN physio...

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Autors principals: Tognon, Raquel, Gasparotto, Elainy PL, Neves, Renata P, Nunes, Natália S, Ferreira, Aline F, Palma, Patrícia VB, Kashima, Simone, Covas, Dimas T, Santana, Mary, Souto, Elizabeth X, Zanichelli, Maria Aparecida, Simões, Belinda P, de Souza, Ana Maria, Castro, Fabíola A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298534/
https://ncbi.nlm.nih.gov/pubmed/22300941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-2
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