Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

BACKGROUND: Gene transfer using non-viral vectors offers a non-immunogenic and safe method of gene delivery. Cellular uptake and intracellular trafficking of the nanoparticles can impact on the transfection efficiency of these vectors. Therefore, understanding the physicochemical properties that may...

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Autors principals: Singh, Jagbir, Michel, Deborah, Chitanda, Jackson M, Verrall, Ronald E, Badea, Ildiko
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298462/
https://ncbi.nlm.nih.gov/pubmed/22296763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-10-7
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