Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

BACKGROUND: Gene transfer using non-viral vectors offers a non-immunogenic and safe method of gene delivery. Cellular uptake and intracellular trafficking of the nanoparticles can impact on the transfection efficiency of these vectors. Therefore, understanding the physicochemical properties that may...

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Autori principali: Singh, Jagbir, Michel, Deborah, Chitanda, Jackson M, Verrall, Ronald E, Badea, Ildiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298462/
https://ncbi.nlm.nih.gov/pubmed/22296763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-10-7
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