Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

Phosphotyrosine-binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targets tyrosine-phosphorylated E-cadherin via an uncharacterized domain. In this study, the crystal structure of Hak...

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Detalhes bibliográficos
Main Authors: Mukherjee, Manjeet, Chow, Soah Yee, Yusoff, Permeen, Seetharaman, J, Ng, Cherlyn, Sinniah, Saravanan, Koh, Xiao Woon, Asgar, Nur Farehan M, Li, Dan, Yim, Daniel, Jackson, Rebecca A, Yew, Jingxi, Qian, Jingru, Iyu, Audrey, Lim, Yoon Pin, Zhou, Xingding, Sze, Siu Kwan, Guy, Graeme R, Sivaraman, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298002/
https://ncbi.nlm.nih.gov/pubmed/22252131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.496
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