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Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition: INSIGHTS FROM SOLUTION STUDIES AND NMR STRUCTURE
Hakai, an E3 ubiquitin ligase, disrupts cell-cell contacts in epithelial cells and is up-regulated in human colon and gastric adenocarcinomas. Hakai acts through its phosphotyrosine-binding (HYB) domain, which bears a dimeric fold that recognizes the phosphotyrosine motifs of E-cadherin, cortactin,...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162166/ https://ncbi.nlm.nih.gov/pubmed/25074933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592840 |
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