Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.

Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by insufficient amounts of alpha 1AT to protect the lower respiratory tract from neutrophil elastase, resulting in emphysema. Yeast-produced recombinant alpha 1AT (rAAT) has normal antielastase function but is associated with high renal cle...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Hubbard, R C, McElvaney, N G, Sellers, S E, Healy, J T, Czerski, D B, Crystal, R G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2794066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114305
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