Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.

Alpha 1-Antitrypsin (alpha 1AT) deficiency is characterized by insufficient amounts of alpha 1AT to protect the lower respiratory tract from neutrophil elastase, resulting in emphysema. Yeast-produced recombinant alpha 1AT (rAAT) has normal antielastase function but is associated with high renal cle...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	J Clin Invest
Autori principali:	Hubbard, R C, McElvaney, N G, Sellers, S E, Healy, J T, Czerski, D B, Crystal, R G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2794066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114305
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!