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EphA2 Receptor Activation by Monomeric Ephrin-A1 on Supported Membranes
The receptor tyrosine kinase EphA2 interacts with its glycosylphosphatidylinositol (GPI)-linked ephrin-A1 ligand in a juxtacrine configuration. The soluble ephrin-A1 protein, without its GPI membrane linker, fails to activate EphA2. However, preclustered ephrin-A1 protein is active in solution and h...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3297811/ https://ncbi.nlm.nih.gov/pubmed/22261062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.039 |
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