Rapid Assembly of a Multimeric Membrane Protein Pore

We have observed the assembly of the staphylococcal pore-forming toxin α-hemolysin using single-molecule fluorescence imaging. Surprisingly, assembly from the monomer to the complete heptamer is extremely rapid, occurring in <5 ms. No lower order oligomeric intermediates are detected. Monte Carlo...

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Bibliografiske detaljer
Main Authors: Thompson, James R., Cronin, Bríd, Bayley, Hagan, Wallace, Mark I.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2011
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297801/
https://ncbi.nlm.nih.gov/pubmed/22261056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.09.054
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