Identification and Structure-Activity Relationships of a Novel Series of Estrogen Receptor Ligands Based on 7-Thiabicyclo[2.2.1]hept-2-ene-7-oxide()

To develop estrogen receptor (ER) ligands having novel structures and activities, we have explored compounds in which the central hydrophobic core has a more three-dimensional topology than typically found in estrogen ligands and thus exploit the unfilled space in the ligand-binding pocket. Here, we...

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Main Authors: Wang, Pengcheng, Min, Jian, Nwachukwu, Jerome C., Cavett, Valerie, Carlson, Kathryn E., Guo, Pu, Zhu, Manghong, Zheng, Yangfan, Dong, Chune, Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297713/
https://ncbi.nlm.nih.gov/pubmed/22283328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201556r
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