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Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and to sheep.

Augmentation of lung antiprotease levels may be an important therapeutic intervention in the prevention of pulmonary emphysema. We have administered aerosols of plasma-derived human alpha 1 proteinase inhibitor (A1PI) to the lungs of dogs and sheep to investigate (a) delivery of the protein to the d...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Smith, R M, Traber, L D, Traber, D L, Spragg, R G
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329771/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2794051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114278
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