High-throughput Examination of FRET-detected Metal-Ion Response in Mammalian Cells

FRET-based genetically encoded metal-ion sensors are important tools for studying metal-ion dynamics in live cells. We present a time-resolved microfluidic flow cytometer capable of characterizing the FRET-based dynamic response of metal-ion sensors in mammalian cells, at a throughput of 15 cells/se...

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Bibliographic Details
Main Authors: Ma, Hairong, Gibson, Emily A., Dittmer, Philip J., Jimenez, Ralph, Palmer, Amy E.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297669/
https://ncbi.nlm.nih.gov/pubmed/22260720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2101592
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