Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination

DNA double strand breaks (DSBs) are repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). The DNA cell cycle stage and resection of the DSB ends are two key mechanisms which are believed to push DSB repair to the HR pathway. Here, we show that the NHEJ factor Ku80 associate...

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Bibliografske podrobnosti
Main Authors: Shao, Zhengping, Davis, Anthony J., Fattah, Kazi R., So, Sairei, Sun, Jingxin, Lee, Kyung-Jong, Harrison, Lynn, Yang, Jun, Chen, David J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297478/
https://ncbi.nlm.nih.gov/pubmed/22265216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.12.007
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