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Preparation, Separation, and Conformational Analysis of Differentially Sulfated Heparin Octasaccharide Isomers using Ion Mobility Mass Spectrometry

Heparin is a linear sulfated polysaccharide widely used in medicine because of its anticoagulant properties. The various sulfation and/or acetylation patterns on heparin impart different degrees of conformational change around the glycosidic bonds and subsequently alter its function as an anticoagul...

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Detalhes bibliográficos
Main Authors: Seo, Youjin, Andaya, Armann, Leary, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296823/
https://ncbi.nlm.nih.gov/pubmed/22283665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac203190k
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