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Insight into the Cooperation of P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) at the Blood-Brain Barrier: A Case Study Examining Sorafenib Efflux Clearance

The ATP-binding cassette transporters p-glycoprotein and breast cancer resistance protein have been shown to be critical determinants limiting drug transport across the BBB into the brain. Several therapeutic agents have been shown to be substrates for these two transporters, and as a result they ha...

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Sonraí Bibleagrafaíochta
Main Authors: Agarwal, Sagar, Elmquist, William F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296237/
https://ncbi.nlm.nih.gov/pubmed/22335402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200465c
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