Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice

Deficiency of ACE2 in macrophages has been suggested to promote the development of an inflammatory M1 macrophage phenotype. We evaluated effects of ACE2 deficiency in bone-marrow-derived stem cells on adipose inflammation and glucose tolerance in C57BL/6 mice fed a high fat (HF) diet. ACE2 activity...

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Autores principales: Thatcher, Sean E., Gupte, Manisha, Hatch, Nicholas, Cassis, Lisa A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296206/
https://ncbi.nlm.nih.gov/pubmed/22518292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/762094
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