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Optimized dextran-polyethylenimine conjugates are efficient non-viral vectors with reduced cytotoxicity when used in serum containing environments

Polyethylenimine (PEI) is a cationic polymer that is an efficient transfection reagent marred by high toxicity and a susceptibility to aggregate in the presence of serum. Dextran is a biodegradable natural polysaccharide that can be used to reduce the toxicity of PEI and increase its stability in th...

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Bibliografiske detaljer
Main Authors: Jiang, Dahai, Salem, Aliasger K
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295901/
https://ncbi.nlm.nih.gov/pubmed/22037445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2011.10.032
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