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Yeast mitochondrial threonyl-tRNA synthetase recognizes tRNA isoacceptors by distinct mechanisms and promotes CUN codon reassignment

Aminoacyl-tRNA synthetases (aaRSs) ensure faithful translation of mRNA into protein by coupling an amino acid to a set of tRNAs with conserved anticodon sequences. Here, we show that in mitochondria of Saccharomyces cerevisiae, a single aaRS (MST1) recognizes and aminoacylates two natural tRNAs that...

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Autores principales: Ling, Jiqiang, Peterson, Kaitlyn M., Simonović, Ivana, Cho, Chris, Söll, Dieter, Simonović, Miljan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295322/
https://ncbi.nlm.nih.gov/pubmed/22343532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200109109
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