Safe and Sustained Vaginal Delivery of Pyrimidinedione HIV-1 Inhibitors from Polyurethane Intravaginal Rings

The potent antiretroviral pyrimidinediones IQP-0528 (PYD1) and IQP-0532 (PYD2) were formulated in polyurethane intravaginal rings (IVRs) as prophylactic drug delivery systems to prevent the sexual transmission of HIV-1. To aid in the selection of a pyrimidinedione candidate and the optimal loading o...

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Detalhes bibliográficos
Main Authors: Johnson, Todd J., Srinivasan, Priya, Albright, Theodore H., Watson-Buckheit, Karen, Rabe, Lorna, Martin, Amy, Pau, Chou-Pong, Hendry, R. Michael, Otten, Ron, McNicholl, Janet, Buckheit, Robert, Smith, James, Kiser, Patrick F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294899/
https://ncbi.nlm.nih.gov/pubmed/22155820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05721-11
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